Of course there's no side effect when you install oTranslate if it didn't exist before.
And the update is basic:
UPDATE tab
SET column2 = NULL
WHERE
column1 IN
(SELECT column1 FROM tab
WHERE CHAR_LENGTH(oTranslate(your_column, 'abcdefghijklmnopqrstuvwxyz','') > 0)
Of course there's no side effect when you install oTranslate if it didn't exist before.
And the update is basic:
Dieter